Bourns Hall

Colloquium

 

Feimeng Zhou Department of Chemistry and Biochemistry California State University, Los Angeles Los Angeles, CA 90032 Surface and Kinetic Studies of Biomolecular Reactions at the Solid/Solution Interface Abstract In this presentation, the applications of several important surface and analytical techniques (e.g., atomic force microscopy, ellipsometry, surface plasmon resonance, and quartz crystal microbalance) to the studies of biomolecular interactions at the solid/solution interface will be described. Particular emphasis will be placed on the work related to the time-lapse atomic force microscopic (AFM) observations of the aggregation and fibrillation of α-synuclein (a protein linked to Parkinson's disease) and other amyloidogenic proteins. The use of AFM and other techniques for real-time monitoring of DNA hybridization and DNA/protein interaction (e.g., the interaction of p53, a tumor-suppression protein, with the consensus double-stranded DNA molecules) will also be presented. Biosketch Feimeng Zhou is a Professor of Chemistry and Biochemistry at California State University, Los Angeles. Professor Zhou's research interests are in: applications of scanning probe microscopic techniques (scanning electrochemical microscopy, atomic force microscopy, and scanning tunneling microscopy); trace metal analysis based on electrochemical and spectroscopic techniques; flow-injection analysis; biosensor development; electron and metal transfer reactions of metalloproteins; and DNA/DNA and DNA/protein interactions. Wednesday, October 27, 2004 Surge 284 10:10 a.m.-11:00 a.m. (Refreshments will be served at 10:00 a.m.)