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John Bischof
Department of Mechanical Engineering, Biomedical Engineering and Urology
University of Minnesota Cells, Molecules and Nanoparticles in Biomedical Heat Transfer Abstract Heat transfer plays a crucial role in many biomedical applications in cryobiology (biopreservation and cryosurgery) and hyperthermic biology (thermal therapies). In these applications, thermal excursions are used to selectively preserve or destroy cells and tissues. Biopreservation is an enabling technology to many biomedical fields including cell and tissue banking, cell therapeutics, tissue engineering, organ transplantation and assisted reproductive technologies. Thermal therapies including cryosurgery are increasingly important in all surgical sub-specialties for minimally invasive thermal destruction of tissues for cancer and cardiovascular disease treatment. In this talk work predominantly from our lab will be reviewed focusing on cellular and molecular phenomena that are important in defining outcomes of both cryobiological and hyperthermic biomedical applications. During these applications microscale cellular phenomena depend on the heat transfer process, such as cellular dehydration, intracellular ice formation, and membrane hyperpermeability and blebbing which are all mechanistically linked to viability change. Molecular and nanoscale events include lipid oxidation, phase change and segregation as well as protein denaturation which are mechanistically linked to viability changes. Function can also be affected as for example both heating and freezing changes to collagen can change biomechanical properties, especially in some cardiovascular tissues. In addition, gene regulated events (inflammation and apoptosis), often in response to thermally triggered molecular changes, have recently been shown to increase thermal destruction of cells. Finally, recent work will be reviewed with iron oxide and gold nanoparticles showing their dramatic potential to both enhance and control thermal therapy outcomes through adjuvant (drug) delivery, tomographic visualization and inductive heating within the body.Biosketch John Bischof is a Professor in the Department of Mechanical Engineering with joint appointments in Biomedical Engineering and Urologic Surgery at the University of Minnesota. Dr. Bischof received a B.S. in Bioengineering from the University of California Berkeley in 1987 and an M.S. from U.C. Berkeley and San Francisco in 1989, and a Ph.D. in Mechanical Engineering from U.C. Berkeley in 1992. After a Post-doctoral Fellowship at Harvard, he joined the University of Minnesota in 1993. Professor Bischof is an author on more than 100 peer reviewed publications; he has several patents filed or issued and numerous Young Investigator and Best Paper awards in bioheat transfer. He is a recipient of the George Taylor Research Award at the University of Minnesota, an Alexander von Humboldt Fellowship and a Japan Society for the Promotion of Science Fellowship.Friday, October 28, 2005
Bourns Hall A265
11:00 a.m.-12:00 p.m.
(Refreshments will be served at 10:30 a.m. in Bourns A171) |
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